| Sr.no. |
Chief Ministers Name |
Took Office |
Left Office |
Party Name |
| 1 | A. Subbarayalu Reddiar | 12/17/20 | 07/11/21 | Justice Party |
| 2 | Raja of Panagal | 07/11/21 | 09/11/23 | Justice Party |
| 3 | Raja of Panagal | 11/19/23 | 12/03/26 | Justice Party |
| 4 | P. Subbarayan | 12/04/26 | 10/27/30 | Unaffiliated |
| 5 | B. Munuswamy Naidu | 10/27/30 | 11/04/32 | Justice Party |
| 6 | Ramakrishna Ranga Rao | 11/05/32 | 11/1934 | Justice Party |
| 7 | Ramakrishna Ranga Rao | 11/1934 | 04/04/36 | Justice Party |
| 8 | P. T. Rajan | 04/04/36 | 08/24/36 | Justice Party |
| 9 | Ramakrishna Ranga Rao | 08/24/36 | 04/01/37 | Justice Party |
| 10 | Kurma Venkata Reddy Naidu | 04/01/37 | 07/14/37 | Interim provisional ministry |
| 11 | C. Rajagopalachari | 07/14/37 | 10/29/39 | Indian National Congress |
| 12 | Governor's Rule | 10/29/39 | 04/30/46 | 0 |
| 13 | Tanguturi Prakasam | 04/30/46 | 03/23/47 | Indian National Congress |
| 14 | O. P. Ramaswamy Reddiyar | 03/23/47 | 04/06/49 | Indian National Congress |
| 15 | P. S. Kumaraswamy Raja | 04/06/49 | 01/26/50 | Indian National Congress |
| 16 | P. S. Kumaraswamy Raja | 01/26/50 | 04/09/52 | Indian National Congress |
| 17 | C. Rajagopalachari | 04/10/52 | 04/13/54 | Indian National Congress |
| 18 | K. Kamaraj | 04/13/54 | 03/31/57 | Indian National Congress |
| 19 | K. Kamaraj | 04/13/57 | 03/01/62 | Indian National Congress |
| 20 | K. Kamaraj | 03/15/62 | 10/02/63 | Indian National Congress |
| 21 | M. Bakthavatsalam | 10/02/63 | 03/06/67 | Indian National Congress |
| 22 | C. N. Annadurai | 03/06/67 | 01/14/69 | DMK |
| 23 | C. N. Annadurai | 01/14/69 | 02/03/69 | DMK |
| 24 | V.R. Nedunchezhiyan (acting) | 02/03/69 | 02/10/69 | DMK |
| 25 | M. Karunanidhi | 02/10/69 | 01/04/71 | DMK |
| 26 | M. Karunanidhi | 03/15/71 | 01/31/76 | DMK |
| 27 | President's rule | 01/31/76 | 06/30/77 | 0 |
| 28 | M. G. Ramachandran | 06/30/77 | 02/17/80 | AIADMK |
| 29 | President's rule | 02/17/80 | 06/09/80 | 0 |
| 30 | M. G. Ramachandran | 06/09/80 | 11/15/84 | AIADMK |
| 31 | M. G. Ramachandran | 02/10/85 | 12/24/87 | AIADMK |
| 32 | V.R. Nedunchezhiyan (acting) | 12/24/87 | 01/07/88 | AIADMK |
| 33 | Janaki Ramachandran | 01/07/88 | 01/30/88 | AIADMK |
| 34 | President's rule | 01/30/88 | 01/27/89 | 0 |
| 35 | M. Karunanidhi | 01/27/89 | 01/30/91 | DMK |
| 36 | President's rule | 01/30/91 | 06/24/91 | 0 |
| 37 | J. Jayalalithaa | 06/24/91 | 05/12/96 | AIADMK |
| 38 | M. Karunanidhi | 05/13/96 | 05/13/01 | DMK |
| 39 | J. Jayalalithaa | 05/14/01 | 09/21/01 | AIADMK |
| 40 | O. Panneerselvam | 09/21/01 | 03/01/02 | AIADMK |
| 41 | J. Jayalalithaa | 03/02/02 | 05/12/06 | AIADMK |
| 42 | M. Karunanidhi | 05/13/06 | 05/15/11 | DMK |
| 43 | J. Jayalalithaa | 05/16/11 | Incumbent | AIADMK |
